T4 Thyroxine 200 x 200mcg Tablets

T4 Thyroxine (200 x 200 mcg) represents a foundational compound for studying the thyroid hormone system, a key regulator of human metabolism and energy balance.
In educational and pharmaceutical science contexts, it serves as a reference molecule for understanding hormone biosynthesis, regulation, and pharmacological replacement mechanisms.

This article provides a comprehensive educational insight into T4’s chemistry, physiological role, and academic research relevance.

2. Chemical and Pharmacological Profile

Chemical Name: L-thyroxine (Tetraiodothyronine)
Molecular Formula: C15H11I4NO4
Molecular Weight: 776.87 g/mol
Drug Class: Thyroid hormone analogue
Type: Synthetic form of naturally occurring thyroxine (T4)

T4 Thyroxine functions as a prohormone, converted into triiodothyronine (T3), the biologically active form responsible for cellular metabolic regulation.

3. Biological Role and Mechanism of Action

The thyroid hormones T3 and T4 are essential regulators of:

Basal metabolic rate
Protein synthesis and lipid metabolism
Thermoregulation and oxygen consumption
Growth and development

Mechanistically, T4 acts as a precursor that undergoes deiodination to form T3. T3 then binds to nuclear thyroid hormone receptors, influencing gene expression and mitochondrial activity.

Educational models emphasize this mechanism to explain nuclear receptor signaling and transcriptional regulation.

4. Educational Importance

T4 Thyroxine 200 mcg is invaluable for teaching:

Endocrine system regulation
Feedback loops involving the hypothalamus and pituitary
Pharmacokinetic modeling of hormone analogues
Molecular signaling in hormone–receptor interactions

Students studying pharmacology and physiology use T4 to understand homeostasis and metabolic adaptation.

5. Endocrine Feedback Regulation

T4 is part of the hypothalamic–pituitary–thyroid (HPT) axis, a key educational concept in endocrinology:

Hypothalamus secretes thyrotropin-releasing hormone (TRH).
Pituitary gland releases thyroid-stimulating hormone (TSH).
Thyroid gland produces and secretes T4 and T3.
High circulating T4 levels provide negative feedback to the pituitary and hypothalamus.

This feedback loop is commonly demonstrated in hormonal regulation coursework.

6. Pharmacokinetics and Metabolism

For educational reference, T4’s pharmacokinetic profile includes:

Absorption: Incomplete but significant oral absorption (~70–80%)
Distribution: High protein binding (thyroxine-binding globulin, transthyretin, albumin)
Metabolism: Deiodination in liver, kidney, and other tissues
Half-life: Approximately 7 days (reflecting stable metabolic function)
Excretion: Primarily via urine and feces

These parameters serve as teaching examples for drug metabolism, protein binding, and systemic bioavailability.

7. Structural and Molecular Characteristics

T4’s structure includes four iodine atoms on a tyrosine-derived backbone, making it highly distinctive in biochemistry.

Educational focus points:

Iodination steps in thyroid hormone synthesis
Thyroglobulin as a precursor molecule
Enzymatic catalysis by thyroid peroxidase

These elements illustrate biosynthetic enzyme activity and trace element dependency (iodine’s biological role).

8. Laboratory and Academic Research Applications

T4 Thyroxine is used in academic laboratories for:

Endocrine feedback modeling
Metabolic rate and oxygen consumption studies
Gene transcription analysis
Pharmacokinetic simulations

In physiology labs, experiments often involve model organisms or cell cultures to measure T4’s metabolic effects.

9. Comparative Educational Studies

Comparisons between T4 and T3 provide valuable educational insights:

Feature	T4 (Thyroxine)	T3 (Triiodothyronine)
Iodine Atoms	4	3
Potency	Lower	Higher
Duration	Longer	Shorter
Role	Prohormone	Active hormone

Such comparisons demonstrate how small structural changes yield significant pharmacological differences.

10. Role in Cellular and Genetic Regulation

Thyroxine’s educational value extends to cellular and molecular biology, as it:

Regulates mitochondrial biogenesis
Enhances protein synthesis and RNA polymerase activity
Influences cellular oxygen utilization
Modulates neural and skeletal development

These aspects make it an ideal example for studying hormone-driven gene expression.

11. Pharmaceutical and Chemical Education

From a pharmaceutical perspective, students can learn about:

Formulation stability of hormone analogues
Storage conditions and degradation pathways
Pharmacological equivalence and bioavailability
Quality assurance in tablet production

This knowledge bridges theoretical biochemistry with industrial pharmaceutical processes.

12. Research in Endocrine and Metabolic Disorders

In educational research, Thyroxine is studied to understand disorders such as:

Hypothyroidism (underactive thyroid)
Hyperthyroidism (overactive thyroid)
Iodine deficiency and metabolic dysregulation

These studies allow medical and pharmacy students to examine clinical physiology and therapeutic mechanism design.

13. Ethical and Educational Handling

T4 Thyroxine 200 mcg should only be used under academic supervision for educational or research demonstrations.
Students are taught about laboratory ethics, controlled handling, and scientific responsibility when using any hormone analogues.

14. Modern Educational Relevance

T4 remains a core topic in:

Biomedical and pharmacology courses
Endocrinology training
Metabolic and biochemical education
Molecular medicine programs

Its use in simulation and biochemical modeling continues to advance understanding of hormonal balance and cellular metabolism.

15. Conclusion

T4 Thyroxine 200 x 200 mcg is not only a synthetic representation of a critical human hormone but also a cornerstone of educational pharmacology and endocrine system learning.

Through the study of its chemical structure, metabolic regulation, and physiological feedback, students gain insight into how hormones maintain homeostasis.
It serves as an essential academic example of biochemical control mechanisms, receptor signaling, and pharmaceutical formulation science.

T4 Thyroxine 200 x 200mcg